Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC028
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-01 10:01
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 4x1/2 tbl Mirapexin a 1,57 1 dnevno Older patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.67 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.67 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 42, 'TN': 30, 'TP': 0, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 28, 'TN': 26, 'TP': 14, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 31, 'TN': 28, 'TP': 11, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 5
timePerCircleMean 9.864
timePerCircleCoV 0.369604
timePerCircleSlope 0.203974
meanError 1.9866
tremorFreq 6.15234
tremorRelPower 38.3151
tremorGyroAmpMean 0.0199068
tremorGyroAmpSlope -0.00704056
tremorGyroAmpCoV 0.387531
tremorCoordAmpMean 0.0397993
tremorCoordAmpSlope -0.0126249
tremorCoordAmpCoV 0.30364
tremorAccAmpMean 0.0719655
tremorAccAmpSlope -0.0028143
tremorAccAmpCoV 0.0654795
tremorPcRelVar 0.678987
tremorPcX -0.529526
tremorPcY -0.848294

Circle Segment 1

Duration 6.4 s, Accuracy Estimate 1.976 (lower is better)

Circle Segment 2

Duration 8.04 s, Accuracy Estimate 2.131 (lower is better)

Circle Segment 3

Duration 9.88 s, Accuracy Estimate 1.989 (lower is better)

Circle Segment 4

Duration 9.04 s, Accuracy Estimate 1.826 (lower is better)

Circle Segment 5

Duration 15.96 s, Accuracy Estimate 2.01 (lower is better)

Spiral

numSpirals 9
timePerSpiralMean 24.2489
timePerSpiralCoV 0.184384
timePerSpiralSlope 0.0175403
meanError 2.70304
tremorFreq 6.34766
tremorRelPower 31.059
tremorGyroAmpMean 0.0210662
tremorGyroAmpSlope -0.00131825
tremorGyroAmpCoV 0.418373
tremorCoordAmpMean 0.0422055
tremorCoordAmpSlope -0.000748502
tremorCoordAmpCoV 0.301744
tremorAccAmpMean 0.0508721
tremorAccAmpSlope -0.000216755
tremorAccAmpCoV 0.132696
tremorPcRelVar 0.563327
tremorPcX 0.405682
tremorPcY -0.914014

Spiral Segment 1

Duration 21.32 s, Accuracy Estimate 2.037 (lower is better)

Spiral Segment 2

Duration 26.16 s, Accuracy Estimate 4.674 (lower is better)

Spiral Segment 3

Duration 18.84 s, Accuracy Estimate 2.033 (lower is better)

Spiral Segment 4

Duration 25.48 s, Accuracy Estimate 2.258 (lower is better)

Spiral Segment 5

Duration 23.96 s, Accuracy Estimate 2.164 (lower is better)

Spiral Segment 6

Duration 26.44 s, Accuracy Estimate 4.68 (lower is better)

Spiral Segment 7

Duration 22.2 s, Accuracy Estimate 2.379 (lower is better)

Spiral Segment 8

Duration 33.76 s, Accuracy Estimate 2.185 (lower is better)

Spiral Segment 9

Duration 20.08 s, Accuracy Estimate 1.918 (lower is better)

Elel

eDurationMean 0.428171
eDurationStd 0.171471
eDurationStdnorm 0.400473
eDurationMedian 0.375
eDurationQuartdelta 0.09625
eDurationQuartdeltanorm 0.256667
eDurationKurt 8.79757
eDurationTrenddiff -0.05
eDurationTrendratio 0.873418
eWidthMean 4.58583
eWidthStd 1.9016
eWidthStdnorm 0.41467
eWidthMedian 4.68
eWidthQuartdelta 2.34
eWidthQuartdeltanorm 0.5
eWidthKurt 4.51883
eWidthTrenddiff -1.053
eWidthTrendratio 0.795455
eHeightMean 10.4587
eHeightStd 2.98039
eHeightStdnorm 0.284968
eHeightMedian 10.53
eHeightQuartdelta 3.744
eHeightQuartdeltanorm 0.355556
eHeightKurt 3.13141
eHeightTrenddiff -2.5155
eHeightTrendratio 0.792271
eAspectMean 0.427945
eAspectStd 0.103479
eAspectStdnorm 0.241805
eAspectMedian 0.438095
eAspectQuartdelta 0.120269
eAspectQuartdeltanorm 0.274526
eAspectKurt 3.21175
eAspectTrenddiff -0.00903814
eAspectTrendratio 0.979569
eSlantMean 0.00602009
eSlantStd 0.142566
eSlantStdnorm 23.6818
eSlantMedian 0.0128205
eSlantQuartdelta 0.207774
eSlantQuartdeltanorm 16.2064
eSlantKurt 2.72629
eSlantTrenddiff -0.0431156
eRtopMean 0.712443
eRtopStd 0.169874
eRtopStdnorm 0.238439
eRtopMedian 0.75
eRtopQuartdelta 0.163837
eRtopQuartdeltanorm 0.218449
eRtopKurt 9.67876
eRtopTrenddiff -0.011163
eRbotMean 0.770131
eRbotStd 0.341321
eRbotStdnorm 0.443198
eRbotMedian 0.675
eRbotQuartdelta 0.457589
eRbotQuartdeltanorm 0.67791
eRbotKurt 4.30561
eRbotTrenddiff 0.0374878
eRrightMean 0.842132
eRrightStd 0.0842264
eRrightStdnorm 0.100016
eRrightMedian 0.8625
eRrightQuartdelta 0.11891
eRrightQuartdeltanorm 0.137867
eRrightKurt 3.06751
eRrightTrenddiff -0.00743827
eRleftMean 0.411082
eRleftStd 0.103881
eRleftStdnorm 0.252702
eRleftMedian 0.411765
eRleftQuartdelta 0.131099
eRleftQuartdeltanorm 0.318383
eRleftKurt 3.2325
eRleftTrenddiff -0.0126041
lDurationMean 0.555132
lDurationStd 0.141505
lDurationStdnorm 0.254903
lDurationMedian 0.5
lDurationQuartdelta 0.12
lDurationQuartdeltanorm 0.24
lDurationKurt 4.64197
lDurationTrenddiff -0.1
lDurationTrendratio 0.831933
lWidthMean 6.15789
lWidthStd 1.09635
lWidthStdnorm 0.17804
lWidthMedian 6.318
lWidthQuartdelta 1.755
lWidthQuartdeltanorm 0.277778
lWidthKurt 2.50568
lWidthTrenddiff -0.936
lWidthTrendratio 0.854545
lHeightMean 21.4911
lHeightStd 5.01263
lHeightStdnorm 0.233242
lHeightMedian 22.0545
lHeightQuartdelta 6.669
lHeightQuartdeltanorm 0.302387
lHeightKurt 2.75356
lHeightTrenddiff -6.318
lHeightTrendratio 0.736585
lAspectMean 0.29785
lAspectStd 0.0756847
lAspectStdnorm 0.254104
lAspectMedian 0.290481
lAspectQuartdelta 0.0564614
lAspectQuartdeltanorm 0.194372
lAspectKurt 5.07636
lAspectTrenddiff 0.0234418
lAspectTrendratio 1.08354
lSlantMean -0.000569354
lSlantStd 0.100354
lSlantStdnorm -176.26
lSlantMedian 0.0222542
lSlantQuartdelta 0.165301
lSlantQuartdeltanorm 7.42783
lSlantKurt 2.68791
lSlantTrenddiff 0.0235294
lRtopMean 0.680337
lRtopStd 0.137528
lRtopStdnorm 0.202147
lRtopMedian 0.693501
lRtopQuartdelta 0.203704
lRtopQuartdeltanorm 0.293732
lRtopKurt 2.7615
lRtopTrenddiff -0.0148148
lRbotMean 0.720603
lRbotStd 0.264406
lRbotStdnorm 0.366922
lRbotMedian 0.629736
lRbotQuartdelta 0.333333
lRbotQuartdeltanorm 0.529323
lRbotKurt 3.30931
lRbotTrenddiff -0.0111111
lRrightMean 0.838751
lRrightStd 0.0777852
lRrightStdnorm 0.0927393
lRrightMedian 0.858551
lRrightQuartdelta 0.0796784
lRrightQuartdeltanorm 0.0928056
lRrightKurt 4.14707
lRrightTrenddiff -0.0093961
lRleftMean 0.459287
lRleftStd 0.138856
lRleftStdnorm 0.30233
lRleftMedian 0.449597
lRleftQuartdelta 0.185652
lRleftQuartdeltanorm 0.41293
lRleftKurt 2.33366
lRleftTrenddiff -0.129211

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.875675
sumTouchScores 16.6378
meanMovementTime 0.755
numTouches 19
undershootPercentage 5.26316
overshootPercentage 5.26316

FITTS Long Modified

meanTouchScore 0.713101
sumTouchScores 12.1227
meanMovementTime 1.17125
numTouches 17
undershootPercentage 11.7647
overshootPercentage 23.5294

ZigZag

numZigzags 5
timePerZigzagMean 27.656
timePerZigzagCoV 0.155569
timePerZigzagSlope -0.0835985
meanError 1.87096
tremorFreq 6.25
tremorRelPower 33.2567
tremorGyroAmpMean 0.0299807
tremorGyroAmpSlope -0.00142784
tremorGyroAmpCoV 0.428251
tremorCoordAmpMean 0.050344
tremorCoordAmpSlope 0.000474091
tremorCoordAmpCoV 0.327526
tremorAccAmpMean 0.0828477
tremorAccAmpSlope 6.12735e-05
tremorAccAmpCoV 0.123804
tremorPcRelVar 0.695787
tremorPcX 0.20248
tremorPcY -0.979286

ZigZag Segment 1

Duration 32.64 s, Accuracy Estimate 1.47 (lower is better)

ZigZag Segment 2

Duration 27.16 s, Accuracy Estimate 2.12 (lower is better)

ZigZag Segment 3

Duration 30.96 s, Accuracy Estimate 1.846 (lower is better)

ZigZag Segment 4

Duration 25.72 s, Accuracy Estimate 1.988 (lower is better)

ZigZag Segment 5

Duration 21.8 s, Accuracy Estimate 1.931 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 11.02
timePerZigzagCoV 0.0831763
timePerZigzagSlope 0.0179414
zigzagHeightMean 61.1716
zigzagHeightCoV 0.077327
zigzagHeightSlope 0.0116975
meanError 0.0467161
tremorFreq 5.37109
tremorRelPower 25.9664
tremorGyroAmpMean 0.0580696
tremorGyroAmpSlope -0.0023399
tremorGyroAmpCoV 0.43756
tremorCoordAmpMean 0.115536
tremorCoordAmpSlope -0.00321103
tremorCoordAmpCoV 0.310364
tremorAccAmpMean 0.0956675
tremorAccAmpSlope -0.00428445
tremorAccAmpCoV 0.30791
tremorPcRelVar 0.710619
tremorPcX -0.217469
tremorPcY -0.976067

ZigZag Offset Segment 1

Duration 11.24 s, Accuracy Estimate 0.044 (lower is better)

ZigZag Offset Segment 2

Duration 10.88 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 3

Duration 9.36 s, Accuracy Estimate 0.075 (lower is better)

ZigZag Offset Segment 4

Duration 11.0 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 5

Duration 12.04 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 6

Duration 11.6 s, Accuracy Estimate 0.055 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.69}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.67}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.8223016045691773}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9214535211747843}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7353582597476578}